别名
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Bravo; hBravo; Neuronal cell adhesion molecule; Ng CAM related; NgCAM related cell adhesion molecule; Nr CAM; Nrcam;
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Clonality
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Monoclonal
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存储缓冲液
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Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
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免疫原
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Recombinant protein of human NrCAM
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稀释度
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WB 1:2000-1:10000, IP 1:20
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参考分子量
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144kDa
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预测分子量
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144kDa
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运输及保存条件
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20°C/1 year
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Human Gene ID
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4897
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基因名称
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NRCAM
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蛋白名称
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KIAA0343
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宿主
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Rabbit
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同种型
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LgG
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组织表达
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Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum,
hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus
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细胞定位
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Cell membrane {ECO:|UniProtKB:Q810U4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q810U4} Cell proje
ction, axon {ECO:0000250|}. Secreted {ECO:0000250|UniProtKB:Q810U4}. Note=Detected at nodes of Ranvier {ECO
:0000250|UniProtKB:Q810U4}
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注意事项
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NRCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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功能
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Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous syst
em. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between
Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of
Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinate
d axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of so
dium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, tog
ether with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
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