您好,欢迎来到上海抚生实业有限公司!
400-990-7709 / 021-52961052(工作日9:00-18:00)
NRCAM (13T10) Rabbit Monoclonal Antibody
A-DK10000
NRCAM (13T10) Rabbit Monoclonal Antibody
货号 纯度 规格 目录价 会员价 库存 数量 购买
A-DK10000-50µl 50µl 50µl ¥1200.00 登录查看
A-DK10000-100µl 100µl 100µl ¥2200.00 登录查看
产品详情

产品名称

NRCAM (13T10) Rabbit Monoclonal Antibody

英文名称

NRCAM (13T10) Rabbit Monoclonal Antibody

类别

抗原抗体

反应种属

Human

应用

WB,IP

别名

Bravo; hBravo; Neuronal cell adhesion molecule; Ng CAM related; NgCAM related cell adhesion molecule; Nr CAM; Nrcam;

Clonality

Monoclonal

存储缓冲液

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

免疫原

Recombinant protein of human NrCAM

稀释度

WB 1:2000-1:10000, IP 1:20

参考分子量

144kDa

预测分子量

144kDa

运输及保存条件

20°C/1 year

Human Gene ID

4897

基因名称

NRCAM

蛋白名称

KIAA0343

宿主

Rabbit

同种型

LgG

组织表达

Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum,

hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus

细胞定位

Cell membrane {ECO:|UniProtKB:Q810U4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q810U4} Cell proje

ction, axon {ECO:0000250|}. Secreted {ECO:0000250|UniProtKB:Q810U4}. Note=Detected at nodes of Ranvier {ECO

:0000250|UniProtKB:Q810U4}

注意事项

NRCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

功能

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous syst
em. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between
Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of
Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinate
d axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of so
dium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, tog
ether with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

                         

Weaxstern blot analysis of NRCAM expression in human forebrain lysate.

                         

Western blot analysis of extracts from Mouse brain tissue using at 1:5000.

Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier.

相关产品
ODO2 Rabbit Polyclonal Antibody
产品编号:A-DK40392 规格:50μg
GCSH Rabbit Polyclonal Antibody
产品编号:A-DK40391 规格:50μg
ODB2 Rabbit Polyclonal Antibody
产品编号:A-DK40390 规格:50μg
DLDH Rabbit Polyclonal Antibody
产品编号:A-DK40389 规格:50μg
LIAS Rabbit Polyclonal Antibody
产品编号:A-DK40388 规格:50μg
LIPT Rabbit Polyclonal Antibody
产品编号:A-DK40387 规格:50μg
ADX Rabbit Polyclonal Antibody
产品编号:A-DK40386 规格:50μg
XCT Rabbit Polyclonal Antibody
产品编号:A-DK40385 规格:50μg
PHF8 Rabbit Polyclonal Antibody
产品编号:A-DK40384 规格:50μg
OGDHL Rabbit Polyclonal Antibody
产品编号:A-DK40383 规格:50μg
NPCL1 Rabbit Polyclonal Antibody
产品编号:A-DK40382 规格:50μg
TUTLA Rabbit Polyclonal Antibody
产品编号:A-DK40381 规格:50μg
STIM2 Rabbit Polyclonal Antibody
产品编号:A-DK40380 规格:50μg
PRD16 Rabbit Polyclonal Antibody
产品编号:A-DK40379 规格:50μg
METL8 Rabbit Polyclonal Antibody
产品编号:A-DK40378 规格:50μg
TXNIP Rabbit Polyclonal Antibody
产品编号:A-DK40377 规格:50μg
WWP1 Rabbit Polyclonal Antibody
产品编号:A-DK40376 规格:50μg
MCLN1 Rabbit Polyclonal Antibody
产品编号:A-DK40375 规格:50μg