| 货号 | 纯度 | 规格 | 目录价 | 会员价 | 库存 | 数量 | 购买 |
|---|---|---|---|---|---|---|---|
| AK96249-100ul | 50ul | 50ul | ¥1580.00 | 登录查看 |
|
产品货号
AK96249
别名
Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin
converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed
angiotensin-converting enzyme 2]
产品名称
ACE2 (2C1) Mouse Monoclonal Antibody
类别
抗原抗体
基因名称
ACE2 UNQ868/PRO1885
蛋白名称
ACE2
推荐应用
WB,IHC,IF
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
制备方法
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope
specific immunogen.
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene ID
59272
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59272
Human Swissprot No.
Q9BYF1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BYF1/entry
Mouse Gene ID
70008
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70008
Mouse Swissprot No.
Q8R0I0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0I0/entry
Rat Gene ID
302668
1 / 2Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302668
Rat Swissprot No.
Q5EGZ1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EGZ1/entry
特异性
This antibody detects endogenous levels of ACE2 at Human, Mouse,Rat
稀释度
WB 1:500-2000, IHC 1:50-200, IF 1:50-200
参考分子量
120-135kD
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
[Processed angiotensin-converting enzyme 2]: Secreted .; Cell membrane ; Single-pass type I
membrane protein . Cytoplasm . Cell projection, cilium . Apical cell membrane . Detected in both
cell membrane and cytoplasm in neurons. .; [Isoform 2]: Apical cell membrane .
功能
cofactor:Binds 1 chloride ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,enzyme
regulation:Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu,
and EDTA, but not by the ACE inhibitors linosipril, captopril and
enalaprilat.,function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of
unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze
apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In
case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the
spike glycoprotein of both coronaviruses.,induction:Up-regulated in failing heart.,PTM:N
glycosylation on Asn-90 may limit SARS infectivity.,similarity:Belongs to the peptidase M2
family.,subunit:Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike
glycoprotein.,tissue specificity:Expressed in endothelial cells from small and large arteries, and in
arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small
intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and
gastrointestinal system.,
扫描二维码
扫描二维码
资料/datasheet
